Studies on the Mechanisms by Which Muscarinic Receptors Might Cause Schizophrenia

Grant number: 509333 | Funding period: 2008 - 2010

Completed

Abstract

Schizophrenia is a severe psychiatric disorder that affects approximately 1% of the population. This project will help define changes in the molecules in the brain of subjects with schizophrenia which are likely to be involved in two symptoms of the disorder, the psychoses and cognitive deficits. Understanding the cause of the cognitive deficits of schizophrenia is a high priority because they are the most disabilitating symptom of the disorder and do not respond to current drug treatments.

Related publications (6)

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Understanding the pathophysiology of schizophrenia: Contributions from the Melbourne Psychiatric Brain Bank

B Dean, D Copolov, E Scarr

2016-11-01

The Melbourne Psychiatric Brain Bank came into existence 25 years ago. This review focusses on lines of research that have used ti..

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Decreased cortical muscarinic M1 receptors in schizophrenia are associated with changes in gene promoter methylation, mRNA and gene targeting microRNA

E Scarr, JM Craig, MJ Cairns, MS Seo, JC Galati, NJ Beveridge, A Gibbons, S Juzva, B Weinrich, M Parkinson-Bates, AP Carroll, R Saffery, B Dean

2013-03-01

Many studies have shown decreased cortical muscarinic M1 receptors (CHRM1) in schizophrenia (Sz), with one study showing Sz can be..

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Muscarinic M1 receptor sequence: Preliminary studies on its effects on cognition and expression

E Scarr, S Sundram, A Deljo, TF Cowie, AS Gibbons, S Juzva, A Mackinnon, SJ Wood, R Testa, C Pantelis, B Dean

2012-06-01

It has been reported that people with schizophrenia who are homozygous at the c.267C>A single nucleotide polymorphism of the choli..

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Effects of benzodiazepine treatment on cortical GABAA and muscarinic receptors: Studies in schizophrenia and rats

MC McLeod, E Scarr, B Dean

2010-09-01

Changes in cortical γ-aminobutyric acid A (GABA<inf>A</inf>) receptors and muscarinic receptors have been reported in schizophreni..

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Regionally-specific changes in levels of tumour necrosis factor in the dorsolateral prefrontal cortex obtained postmortem from subjects with major depressive disorder

B Dean, N Tawadros, E Scarr, AS Gibbons

2010-01-01

Background: From studies in the periphery, changed levels of tumour necrosis factor (TNF) have been implicated in the pathophysiol..

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Evolution of the human CNS cholineric system: Has this resulted in the emergence of psychiatric disease?

B Dean

2009-11-01

The aim of the present study was to review the available literature on the evolutionary processes that have led to the develzopmen..